A signal-equalizing system for multi-rate signals and a signal-equalizing method for the system are provided. The system stores a number of compensation methods of equalization. The method includes the steps: acquiring all transmission rates of a multi-rate signal, loading output documents of a signal simulation software, wherein the output documents comprise channel loss values of all transmission rates of the multi-rate signal and selecting a compensation method based on channel loss in the course of the multi-rate signal transmitted and differences among all transmission rates of the multi-rate signal from the plurality of compensation methods of equalization.