发明申请
US20130243771A1 HIGHLY EFFECTIVE ANTI-CADHERIN ANTIBODY FOR INDUCTION OF ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY IN VIVO
审中-公开
用于诱导体内抗体依赖性细胞毒性的高效抗CAD抗体
- 专利标题： HIGHLY EFFECTIVE ANTI-CADHERIN ANTIBODY FOR INDUCTION OF ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY IN VIVO
- 专利标题（中）： 用于诱导体内抗体依赖性细胞毒性的高效抗CAD抗体
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申请号： US13886766申请日： 2013-05-03
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公开(公告)号： US20130243771A1公开(公告)日： 2013-09-19
- 发明人: Hiroyuki ABURATANI , Lilin ZHANG , Keisuke ISHII , Katsushi KOUDA , Aya SAKAMOTO , Keiko KATSUMI , Hiroshi ONISHI , Yoko KAYUKAWA
- 申请人： THE UNIVERSITY OF TOKYO , PERSEUS PROTEOMICS INC.
- 申请人地址： JP TOKYO JP TOKYO
- 专利权人： PERSEUS PROTEOMICS INC.,THE UNIVERSITY OF TOKYO
- 当前专利权人： PERSEUS PROTEOMICS INC.,THE UNIVERSITY OF TOKYO
- 当前专利权人地址： JP TOKYO JP TOKYO
- 优先权： JP2009-111834 20090501; JP2010-018416 20100129
- 主分类号： C07K16/30
- IPC分类号： C07K16/30
摘要：
It is an object of the present invention to provide an anti-cadherin antibody having high antibody-dependent cellular cytotoxicity. The present invention provides an anti-cadherin antibody, which recognizes any one of an upstream region of EC1, a cadherin domain 4 (EC4) and a cadherin domain 5 (EC5), wherein an antibody-dependent cellular cytotoxicity at an antibody concentration of 1 μg/mL is 30% or more.
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