发明申请
- 专利标题： NOTCH1 BINDING AGENTS AND METHODS OF USE THEREOF
- 专利标题（中）： NOTCH1结合剂及其使用方法
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申请号： US13797374申请日： 2013-03-12
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公开(公告)号： US20130243774A1公开(公告)日： 2013-09-19
- 发明人: Edward Thein Htun van der HORST , Austin L. GURNEY , Timothy Charles HOEY , Maureen Fitch BRUHNS , Fumiko Takada AXELROD
- 申请人： ONCOMED PHARMACEUTICALS, INC.
- 申请人地址： US CA Redwood City
- 专利权人： OncoMed Pharmaceuticals, Inc.
- 当前专利权人： OncoMed Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Redwood City
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K45/06 ; C07K16/28
摘要：
The present invention relates to Notch1 binding agents and methods of using the agents for treating diseases, such as hematologic cancers. The present invention provides antibodies that specifically bind to a non-ligand binding membrane proximal region of the extracellular domain of human Notch1. The present invention further provides methods of using agents that inhibit Notch1 activity for treating cancer. Also described are methods of treating hematologic cancers comprising administering a therapeutically effective amount of a binding agent or antibody of the present invention to a subject having a hematologic cancer such as T-cell lymphoblastic leukemia.
公开/授权文献
- US09132189B2 Notch1 binding agents and methods of use thereof 公开/授权日：2015-09-15