发明申请
US20130244253A1 COMPOUNDS HAVING ACTIVITY OF SUPPRESSING ACTIVATION OF TGF-BETA RECEPTOR, METHOD FOR SCREENING OF THE COMPOUNDS, AND COMPOSITION FOR PREVENTING OR TREATING DISEASE CAUSED BY HEPATITIS C VIRUS
有权
具有抑制TGF-β受体激活活性的化合物，化合物筛选方法以及用于预防或治疗由丙型肝炎病毒引起的疾病的组合物
- 专利标题： COMPOUNDS HAVING ACTIVITY OF SUPPRESSING ACTIVATION OF TGF-BETA RECEPTOR, METHOD FOR SCREENING OF THE COMPOUNDS, AND COMPOSITION FOR PREVENTING OR TREATING DISEASE CAUSED BY HEPATITIS C VIRUS
- 专利标题（中）： 具有抑制TGF-β受体激活活性的化合物，化合物筛选方法以及用于预防或治疗由丙型肝炎病毒引起的疾病的组合物
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申请号： US13819979申请日： 2011-08-30
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公开(公告)号： US20130244253A1公开(公告)日： 2013-09-19
- 发明人: Soichi Kojima , Mitsuko Hara , Takehisa Matsumoto , Daisuke Takaya
- 申请人： Soichi Kojima , Mitsuko Hara , Takehisa Matsumoto , Daisuke Takaya
- 申请人地址： JP Wako-shi, Saitama
- 专利权人： RIKEN
- 当前专利权人： RIKEN
- 当前专利权人地址： JP Wako-shi, Saitama
- 优先权： JP2010-192803 20100830
- 国际申请： PCT/JP2011/069620 WO 20110830
- 主分类号： C12N9/99
- IPC分类号： C12N9/99 ; C07K16/28 ; C07K16/40
摘要：
An object is to provide a compound capable of inhibiting activation of TGF-β receptors due to HCV, and a screening method for the compound. It has been found that a HCV-derived NS3 protease binds to type I TGF-β receptor, and this binding results in activation of TGF-β receptors. Moreover, binding sites between the NS3 protease and type I TGF-β receptor were identified, and it has been found that antibodies recognizing these binding sites inhibit activation of TGF-β receptors due to NS3 protease. Furthermore, it has been also found that screening for a compound capable of inhibiting activation of TGF-β receptors can be performed by using the inhibition of the binding between NS3 protease and type I TGF-β receptor or the like as an index.
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