- 专利标题: METHODS FOR PREVENTING OR TREATING MITOCHONDRIAL PERMEABILITY TRANSITION
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申请号: US13778994申请日: 2013-02-27
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公开(公告)号: US20130244957A1公开(公告)日: 2013-09-19
- 发明人: Hazel H. Szeto , Peter W. Schiller , Kesheng Zhao
- 申请人: Hazel H. Szeto , Peter W. Schiller , Kesheng Zhao
- 主分类号: A61K38/07
- IPC分类号: A61K38/07
摘要:
The invention provides a method of reducing or preventing mitochondrial permeability transitioning. The method comprises administering an effective amount of an aromatic-cationic peptide having at least one net positive charge; a minimum of four amino acids; a maximum of about twenty amino acids; a relationship between the minimum number of net positive charges (pm) and the total number of amino acid residues (r) wherein 3pm is the largest number that is less than or equal to r+1; and a relationship between the minimum number of aromatic groups (a) and the total number of net positive charges (pt) wherein 2 a is the largest number that is less than or equal to pt+1, except that when a is 1, pt may also be 1.
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