- 专利标题： G PROTEIN COUPLED RECEPTORS AND USES THEREOF
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申请号： US13796312申请日： 2013-03-12
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公开(公告)号： US20130247233A1公开(公告)日： 2013-09-19
- 发明人: George A. Gaitanaris , John E. Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie L. McIlwain , Maria N. Pavlova , Demetri Vassilatis , Hongkui Zeng
- 申请人： George A. Gaitanaris , John E. Bergmann , Alexander Gragerov , John Hohmann , Fusheng Li , Linda Madisen , Kellie L. McIlwain , Maria N. Pavlova , Demetri Vassilatis , Hongkui Zeng
- 申请人地址： US WA Seattle
- 专利权人： OMEROS CORPORATION
- 当前专利权人： OMEROS CORPORATION
- 当前专利权人地址： US WA Seattle
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C07K14/705
摘要：
The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are useful, for example, in methods of diagnosis and treatment of diseases and disorders. The invention also provides methods for identifying compounds (e.g., agonists or antagonists) using the GPCR polypeptides and polynucleotides of the invention, and for treating conditions associated with GPCR dysfunction with the GPCR polypeptides, polynucleotides, or identified compounds. The invention also provides diagnostic assays for detecting diseases or disorders associated with inappropriate GPCR activity or levels.
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