发明申请
US20130267688A1 Novel antibody structures derived from human germline sequences
审中-公开
衍生自人种系序列的新型抗体结构
- 专利标题： Novel antibody structures derived from human germline sequences
- 专利标题（中）： 衍生自人种系序列的新型抗体结构
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申请号： US13327752申请日： 2012-02-21
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公开(公告)号： US20130267688A1公开(公告)日： 2013-10-10
- 发明人: Li-Te Chin , Chishih Chu , Shu Ching Hsu
- 申请人： Li-Te Chin , Chishih Chu , Shu Ching Hsu
- 主分类号： C07K16/28
- IPC分类号： C07K16/28
摘要：
In order to provide necessary information for the production of complete human monoclonal antibodies capable of human CD152 (CTLA-4) binding, the primary structures of heavy and light chains have been elucidated. The novel amino acid sequence of identified heavy and light chains are derived from VH3 and Vλ germline genes, respectively. Antibodies comprising such novel structures cause specific binding to soluble recombinant human CD152 as well as to activated human peripheral T cells, where the expression of CD152 has been elevated.
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