A universal gun cleaning patch assembly comprising a support frame having a hub and hub bore, a plurality of resiliently deformable legs, and a swab. The assembly is radially compressible to effectively wipe the bores of weapons having a wide range of bore diameters. The swab material is preferably made integral with the support frame and may include natural or synthetic fibers and/or laminates of natural and/or synthetic fibers and a metal or plastic mesh embedded in a fabric to effectively scrub the inner bore of the firearm and remove gunpowder residues and excess solvents or oils during the cleaning process. The hub bore may sized to be self-tapping on male threads of a cable or rod that is pulled and/or pushed through the bore, or the bore may be tapered and include a plurality of deformable fingers to received a quick-disconnect stem.