A scrub brush for cleaning arms, hands, and fingernails includes a reservoir for applying an antiseptic or cleaning composition and first and second groups of bristles having different relative flexibilities. The reservoir can be an absorbent open-foam material capable of absorbing and holding a liquid cleaning composition. The first bristles are designed to gently cleanse skin surfaces without scratching, gouging, scraping or otherwise damaging skin. The second bristles are more rigid than the first bristles to more aggressively scrub dirt, microbes or other foreign debris from gaps underneath fingernails. A finger alignment guide adjacent to the stiffer bristles maintains proper alignment between fingernails and the stiffer bristles so that the bristles enter gaps underneath the fingernails when the fingers are moved in a back and forth motion.