发明申请
US20130281460A1 6-THIO-SUBSTITUTED IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS
有权
用作MPS-1和TKK抑制剂治疗高血压疾病的6-THIO替代的咪达唑仑
- 专利标题： 6-THIO-SUBSTITUTED IMIDAZOPYRAZINES FOR USE AS MPS-1 AND TKK INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISORDERS
- 专利标题（中）： 用作MPS-1和TKK抑制剂治疗高血压疾病的6-THIO替代的咪达唑仑
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申请号： US13995055申请日： 2011-12-13
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公开(公告)号： US20130281460A1公开(公告)日： 2013-10-24
- 发明人: Marcus Koppitz , Ulrich Klar , Rolf Jautelat , Dirk Kosemund , Rolf Bohlmann , Benjamin Bader , Philip Lienau , Gerhard Siemeister
- 申请人： Marcus Koppitz , Ulrich Klar , Rolf Jautelat , Dirk Kosemund , Rolf Bohlmann , Benjamin Bader , Philip Lienau , Gerhard Siemeister
- 申请人地址： DE Monheim
- 专利权人： BAYER INTELLECTUAL PROPERTY GMBH
- 当前专利权人： BAYER INTELLECTUAL PROPERTY GMBH
- 当前专利权人地址： DE Monheim
- 优先权： EP10195699.3 20101217
- 国际申请： PCT/EP2011/072582 WO 20111213
- 主分类号： C07D487/04
- IPC分类号： C07D487/04
摘要：
The present invention relates to substituted imidazopyrazine compounds of general formula (I): (I) in which R1, R2, R3, R4 and R5 are as defined in the claims, to methods of and intermediates for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
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