发明申请
- 专利标题: NOVEL INDOLE OR INDAZOLE DERIVATIVE OR SALT THEREOF
- 专利标题(中): 新颖的吲哚或吲哚衍生物或其盐
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申请号: US13978632申请日: 2012-01-06
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公开(公告)号: US20130289072A1公开(公告)日: 2013-10-31
- 发明人: Makoto Kitade , Shuichi Ohkubo , Chihoko Yoshimura
- 申请人: Makoto Kitade , Shuichi Ohkubo , Chihoko Yoshimura
- 申请人地址: JP TOKYO
- 专利权人: TAIHO PHARMACEUTICAL CO., LTD.
- 当前专利权人: TAIHO PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: JP TOKYO
- 优先权: JP2011-002147 20110107
- 国际申请: PCT/JP12/50140 WO 20120106
- 主分类号: C07D401/14
- IPC分类号: C07D401/14 ; C07D403/14
摘要:
The present invention relates to provision of a novel indazole compound which is capable of inhibiting HSP90 and shows a cytostatic effect on cancer cells. The present invention also relates to provision of a drug useful for preventing and/or treating, on the basis of an HSP90 inhibitory effect, a disease in which HSP90 participates, in particular, cancer. A compound represented by the general formula (I) or a salt thereof: wherein X represents CH or N; any one or two of Y1, Y2, Y3, and Y4 represent C—R3 or N, and the others represent CH; A and B are the same or different and represent an optionally substituted monocyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S, and O; R1 represents a hydrogen atom, an optionally substituted alkyl group having 1 to 6 carbon atoms etc.; R2 represents a hydrogen atom, a halogen atom etc.; R3 represents a hydrogen atom, a halogen atom etc.; R4 and R5 are the same or different and represent a hydroxyl group etc.; R6 and R7 are the same or different and represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms etc.; and R8 represents an optionally substituted cycloalkyl group having 3 to 7 carbon atoms etc.
公开/授权文献
- US09120780B2 Indole or indazole derivative or salt thereof 公开/授权日:2015-09-01
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