A method of manufacturing an optical fibre preform includes: producing a core rod having a core rod diameter; inserting the core rod into a glass fluorine-doped intermediate cladding tube so as to form a core assembly, the intermediate cladding tube having an inner diameter and an outer diameter, wherein the inner diameter is larger than the core rod diameter, the radial difference between the inner diameter and the core rod diameter defining an annular gap; and applying a negative pressure inside the annular gap; and forming a core preform by heating the core assembly to collapse the intermediate cladding tube around the core rod while maintaining the negative pressure, wherein heating includes moving a heater outside the intermediate cladding tube and along an axial direction of the same, and forming an overcladding region surrounding the core preform so as to form an optical fibre preform.