发明申请
- 专利标题: IL-1 BINDING PROTEINS
- 专利标题(中): IL-1结合蛋白
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申请号: US13775540申请日: 2013-02-25
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公开(公告)号: US20130295004A1公开(公告)日: 2013-11-07
- 发明人: Chung-ming Hsieh , Chengbin Wu , Renee Miller , Dominic J. Ambrosi
- 申请人: Chung-ming Hsieh , Chengbin Wu , Renee Miller , Dominic J. Ambrosi
- 主分类号: C07K16/24
- IPC分类号: C07K16/24 ; A61K39/395 ; A61K45/06 ; C12N9/96
摘要:
The present invention describes IL-1β binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1β. Binding proteins of the invention have high affinity for IL-1β and neutralize IL-1β activity. A binding protein of the invention can be a full-length antibody or an IL-1β-binding portion thereof. Methods of making and methods of using the binding proteins of the invention are also described. The IL-1β binding proteins of the invention are useful for detecting IL-1β and for inhibiting IL-1β activity, including in a human subject suffering from a disease or disorder in which IL-1β activity is detrimental.
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