发明申请
US20130296281A1 Aryl Substituted Indoles and Their Use as Blockers of Sodium Channels
有权
芳基取代的吲哚及其作为钠通道阻断剂的用途
- 专利标题： Aryl Substituted Indoles and Their Use as Blockers of Sodium Channels
- 专利标题（中）： 芳基取代的吲哚及其作为钠通道阻断剂的用途
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申请号： US13704531申请日： 2011-06-16
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公开(公告)号： US20130296281A1公开(公告)日： 2013-11-07
- 发明人: Donald J. Kyle , Chiyou Ni , Laykea Tafesse , Jiangchao Yao
- 申请人： Donald J. Kyle , Chiyou Ni , Laykea Tafesse , Jiangchao Yao
- 申请人地址： US CT Stamford
- 专利权人： Purdue Pharma L.P.
- 当前专利权人： Purdue Pharma L.P.
- 当前专利权人地址： US CT Stamford
- 国际申请： PCT/IB2011/001382 WO 20110616
- 主分类号： C07D209/20
- IPC分类号： C07D209/20 ; C07D209/12 ; C07D401/12 ; C07D209/18 ; C07D231/56 ; G01N33/50 ; C07D413/06 ; C07D209/14 ; C07D471/04
摘要：
The invention relates to aryl and heteroaryl substituted compounds of Formula (I), and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein G, R1, and Z1-Z5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.