发明申请
- 专利标题: NOVEL BICYCLIC COMPOUND OR SALT THEREOF
- 专利标题(中): 新型双环化合物或其盐
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申请号: US13978613申请日: 2012-01-06
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公开(公告)号: US20130296320A1公开(公告)日: 2013-11-07
- 发明人: Makoto Kitade , Satoshi Yamashita , Shuichi Ohkubo
- 申请人: Makoto Kitade , Satoshi Yamashita , Shuichi Ohkubo
- 申请人地址: JP Tokyo
- 专利权人: TAIHO PHARMACEUTICAL CO., LTD.
- 当前专利权人: TAIHO PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: JP Tokyo
- 优先权: JP2011-002104 20110107
- 国际申请: PCT/JP12/50141 WO 20120106
- 主分类号: C07D401/14
- IPC分类号: C07D401/14 ; C07D403/14 ; C07D403/04 ; C07D417/04 ; C07D413/04 ; C07D401/04 ; C07D471/04
摘要:
Provided is a novel bicyclic compound which has an HSP90 inhibitory effect and a carcinostatic effect. Also provided is a pharmaceutical agent which is based on the HSP90 inhibitory effect and is useful in the prevention and/or treatment of a disease involving HSP90, particularly, cancer. The present invention provides a compound represented by the following general formula (I) or a salt thereof wherein at least one of X1, X2, X3, and X4 represents N or N-oxide and the rest thereof are the same or different and each represent C—R2; any one or two of Y1, Y2, Y3, and Y4 represent C—R4 and the rest thereof are the same or different and each represent CH or N; R1 represents an optionally substituted monocyclic or bicyclic unsaturated heterocyclic group having 1 to 4 heteroatoms selected from N, S, and O; R2 represents a hydrogen atom, an optionally substituted alkyl group having 1 to 6 carbon atoms etc.; R3 represents a hydrogen atom, —CO—R5 etc.; R4 represents a hydrogen atom, —CO—R6, —N(R7)(R8) etc.; R5 represents a hydroxyl group, an amino group etc.; R6 represents a hydroxyl group etc.; R7 and R8 are the same or different and each represent a hydrogen atom, an optionally substituted alkyl group having 1 to 6 carbon atoms etc.; and R9 represents an optionally substituted cycloalkyl group having 3 to 7 carbon atoms etc.
公开/授权文献
- US08912181B2 Bicyclic compound or salt thereof 公开/授权日:2014-12-16
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