发明申请
- 专利标题： OXYPYRIMIDINES AS SYK MODULATORS
- 专利标题（中）： 氧化亚胺作为SYK调节剂
-
申请号： US13882958申请日： 2011-11-01
-
公开(公告)号： US20130317029A1公开(公告)日： 2013-11-28
- 发明人: Anjali Pandey , Qing Xu , Wolin Huang , Zhaozhong J. Jia , Yonghong Song
- 申请人： Anjali Pandey , Qing Xu , Wolin Huang , Zhaozhong J. Jia , Yonghong Song
- 申请人地址： US CA South San Francisco
- 专利权人： PORTOLA PHARMACEUTICALS, INC.
- 当前专利权人： PORTOLA PHARMACEUTICALS, INC.
- 当前专利权人地址： US CA South San Francisco
- 国际申请： PCT/US11/58822 WO 20111101
- 主分类号： C07D239/48
- IPC分类号： C07D239/48 ; C07D405/12 ; C07D417/12 ; C07D403/12 ; C07D401/12
摘要：
The present invention is directed to compounds of formula (I) and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which arc inhibitor of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
信息查询
