Invention Application
- Patent Title: NITRIC OXIDE DONOR NEPRILYSIN INHIBITORS
- Patent Title (中): NITRIC氧化尼龙抑制剂
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Application No.: US13905338Application Date: 2013-05-30
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Publication No.: US20130323271A1Publication Date: 2013-12-05
- Inventor: Mathai Mammen , Adam D. Hughes
- Applicant: Mathai Mammen , Adam D. Hughes
- Main IPC: C07C233/56
- IPC: C07C233/56 ; A61K31/42 ; C07D271/04 ; C07D413/12 ; A61K31/4245 ; A61K31/216 ; C07D261/18 ; A61K45/06

Abstract:
In one aspect, the invention relates to compounds having the formula: where R1, R2, R3, R7, R8, Z, X, b, and c are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds are nitric oxide donors and have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
Public/Granted literature
- US09045443B2 Nitric oxide donor neprilysin inhibitors Public/Granted day:2015-06-02
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