Systems, methods, and devices are provided to calibrate an electronic display to reduce or eliminate mura artifacts. Such mura artifacts may be due to differential behavior of multiple common voltage layers (VCOMs) of the display. One method for reducing or eliminating such muras may involve setting pixels of an electronic display to a gray level and setting an operating parameter of the liquid crystal display to a starting value. An image of the pixels may be captured. Using the image, an average luminance of the pixels may be determined and the image may be amplified around the average luminance to enhance contrast of the image. When the amplified image substantially does not indicates the presence of a mura, the value of the operating parameter may be stored in the electronic display.