In embodiments of selective illumination, an illumination system includes light sources implemented for selective illumination of a target within a field of view of an imaging system. The illumination system also includes optics that can be positioned to direct light that is generated by a subset of the light sources to illuminate a region within the field of view. An imaging application can activate the subset of the light sources and position the optics to illuminate the region within the field of view that includes the target of the selective illumination.