- 专利标题： MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION
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申请号： US13503645申请日： 2010-10-22
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公开(公告)号： US20130338154A1公开(公告)日： 2013-12-19
- 发明人: P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender
- 申请人： P. Jeffrey Conn , Craig W. Lindsley , Corey R. Hopkins , Colleen M. Niswender
- 申请人地址： US TN Nashville
- 专利权人： Vanderbilt University
- 当前专利权人： Vanderbilt University
- 当前专利权人地址： US TN Nashville
- 国际申请： PCT/US10/53837 WO 20101022
- 主分类号： C07D401/12
- IPC分类号： C07D401/12 ; A61K31/4025 ; A61K31/4439 ; C07D207/48 ; A61K31/40 ; C07D417/12 ; A61K31/427 ; C07D403/12 ; A61K31/506 ; C07D401/14 ; A61K31/4709 ; C07D413/14 ; A61K31/538 ; A61K45/06 ; C07D405/12
摘要：
Pyrrole compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
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