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发明申请
US20130345464A1 I-AND II-TYPE CRYSTALS OF L-A-GLYCERYL PHOSPHORYL CHOLINE, AND METHOD FOR PREPARING SAME 有权
L-A-GLYCERYL PHOSPHORYL CHOLINE的I型和II型晶体及其制备方法

  • 专利标题： I-AND II-TYPE CRYSTALS OF L-A-GLYCERYL PHOSPHORYL CHOLINE, AND METHOD FOR PREPARING SAME
  • 专利标题（中）： L-A-GLYCERYL PHOSPHORYL CHOLINE的I型和II型晶体及其制备方法
  • 申请号： US14003276
    申请日： 2012-02-22
  • 公开(公告)号： US20130345464A1
    公开(公告)日： 2013-12-26
  • 发明人: Min-Keun Oh , Ki-Nam Kim , Ki-Hyeong Seo , Dae-Gil Kwon
  • 申请人： Min-Keun Oh , Ki-Nam Kim , Ki-Hyeong Seo , Dae-Gil Kwon
  • 申请人地址： KR Pyeongtaek-si
  • 专利权人： Hanseochem co., ltd
  • 当前专利权人： Hanseochem co., ltd
  • 当前专利权人地址： KR Pyeongtaek-si
  • 优先权： KR1020110022392 20110314; KR1020110022393 20110314
  • 国际申请： PCT/KR2012/001331 WO 20120222
  • 主分类号： C07F9/09
  • IPC分类号： C07F9/09
I-AND II-TYPE CRYSTALS OF L-A-GLYCERYL PHOSPHORYL CHOLINE, AND METHOD FOR PREPARING SAME
摘要：
The present invention relates to I- and II-type crystals of L-α-glyceryl phosphoryl choline, and to a method for preparing same. More particularly, the present invention relates to noble I- and II-type anhydride crystals of L-α-glyceryl phosphoryl choline, which have a higher purity than conventional liquid L-α-glyceryl phosphoryl choline, and one advantage of which is that formulations and dosages of pharmaceuticals are easily modified, and another advantage of which is that the hygroscopicity of the crystals are much lower than that of conventional polymorphic crystals, providing excellent stability during storage. The present invention also relates to a method for preparing the I- and II-type crystals of L-α-glyceryl phosphoryl choline.
摘要（中）：

本发明涉及L-α-甘油磷酰胆碱的I型和II型晶体及其制备方法。 更具体地，本发明涉及具有比常规液体L-α-甘油磷酰胆碱更高纯度的L-α-甘油磷酰胆碱的高级I型和II型酸酐晶体，其优点之一是制剂 并且药物的剂量容易改性，其另一个优点是结晶的吸湿性远低于常规多晶型晶体的吸湿性，在储存期间提供极好的稳定性。 本发明还涉及一种制备L-α-甘油磷酰胆碱的I型和II型晶体的方法。

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