A targeted disambiguation system is described herein which determines true mentions of a list of named entities in a collection of documents. The list of named entities is homogenous in the sense that the entities pertain to the same subject matter domain. The system determines the true mentions by leveraging the homogeneity in the list, and, more specifically by applying a context similarity hypothesis, a co-mention hypothesis, and an interdependency hypothesis. In one implementation, the system executes its analysis using a graph-based model. The system can operate without the existence of additional information regarding the entities in the list; nevertheless, if such information is available, the system can integrate it into its analysis.