A thread-in drain for lavatories includes a flanged and threaded pipe inserted into the lavatory drain waste hole from above said hole for connection to plumbing below said hole. Said flange is secured to the inside of the vessel by tightening a nut and washers threaded onto said pipe from below the vessel. Cross-hairs found in traditional lavatory drains are eliminated. A plurality of closures and grates and screens can be introduced and fixed onto the drain by threading an attached male thread ring on the bottom of said introduced piece into a female thread groove on the upmost interior of said threaded pipe. Said thread-in drain allows for removal and sterilization of said introduced piece. Said thread-in drain allows for access to the interior of the drain by cleaning devices. Said thread-in drain allows for uniform distribution of anti-microbial coating in the interior of said drain.