A gas-liquid catalyzed reaction is performed by introducing at least a portion of the reactive gas into the catalyst as a cross-flow or radial-flow stream. Introducing at least a portion of the reactive gas as a radial flow stream allows the reactive gas to travel through the catalyst bed along a shorter path length. This reduces the pressure drop for the radial flow portion of the gas. The reactive gas can be introduced into the catalyst bed at various heights relative to the height of the catalyst bed.