发明申请
US20140004116A1 METHODS OF PREVENTING OR TREATING PAIN USING ANTI-NGF ANTIBODIES
有权
使用抗NGF抗体预防或治疗疼痛的方法
- 专利标题: METHODS OF PREVENTING OR TREATING PAIN USING ANTI-NGF ANTIBODIES
- 专利标题(中): 使用抗NGF抗体预防或治疗疼痛的方法
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申请号: US13834889申请日: 2013-03-15
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公开(公告)号: US20140004116A1公开(公告)日: 2014-01-02
- 发明人: Leon F. Garcia-Martinez , John A. Latham , Ethan W. Ojala , Corinne C. Akatsuka , Pei Fan , Jeffrey T.L. Smith , Benjamin H. Dutzar
- 申请人: Leon F. Garcia-Martinez , John A. Latham , Ethan W. Ojala , Corinne C. Akatsuka , Pei Fan , Jeffrey T.L. Smith , Benjamin H. Dutzar
- 主分类号: C07K16/22
- IPC分类号: C07K16/22 ; A61K45/06 ; A61K39/395
摘要:
Antibodies and antibody fragments thereof with binding specificity to human Nerve Growth Factor (NGF) and methods of use for treating pain. Methods of treating pain or eliciting an analgesic effect comprising administering an effective amount of an anti-human NGF antibody or antibody fragment thereof, which inhibits the association of NGF with TrkA, and/or p75. These methods may optionally further comprising administering an effective amount of a second anti-human NGF antibody or fragment thereof (e.g., one which inhibits the association of NGF with p75, or one that inhibits the association of NGF with TrkA.)
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