发明申请
US20140005369A1 URIDINE-BASED GADOLINIUM COMPLEX AND MRI CONTRAST AGENT INCLUDING THE SAME
有权
基于尿苷的钆复合物和MRI对照药物，包括它们
- 专利标题： URIDINE-BASED GADOLINIUM COMPLEX AND MRI CONTRAST AGENT INCLUDING THE SAME
- 专利标题（中）： 基于尿苷的钆复合物和MRI对照药物，包括它们
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申请号： US14004831申请日： 2012-03-15
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公开(公告)号： US20140005369A1公开(公告)日： 2014-01-02
- 发明人: Jong-Seung Kim , Sankarprasad Bhuniya , Sumin Lee , Kwan Soo Hong , Hyunseung Lee , Hyeyoung Moon
- 申请人： Jong-Seung Kim , Sankarprasad Bhuniya , Sumin Lee , Kwan Soo Hong , Hyunseung Lee , Hyeyoung Moon
- 申请人地址： KR Daejeon KR Seoul
- 专利权人： KOREA BASIC SCIENCE INSTITUTE,KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
- 当前专利权人： KOREA BASIC SCIENCE INSTITUTE,KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
- 当前专利权人地址： KR Daejeon KR Seoul
- 优先权： KR10-2011--24292 20110318
- 国际申请： PCT/KR12/01864 WO 20120315
- 主分类号： C07H23/00
- IPC分类号： C07H23/00 ; C07H19/067
摘要：
The present invention relates to a new uridine nucleoside-based amphiphilic gadolinium complex and a magnetic resonance imaging (MRI) contrast agent including the gadolinium complex. The MRI contrast agent has high relaxivity, high binding affinity for and stability in human serum albumin, pH response, and high liver specificity.