A method and system for large data and distributed disk cache processing in a Pneuron platform 100. The system and method include three specific interoperable but distributed functions: the adapter/cache Pneuron 14 and distributed disk files 34, a dynamic memory mapping tree 50, and distributed disk file cleanup 28. The system allows for large data processing considerations and the ability to access and acquire information from large data files 102 and rapidly distribute and provide the information to subsequent Pneurons 104 for processing. The system also provides the ability to store large result sets, the ability to deal with sequential as well as asynchronous parallel processing, the ability to address large unstructured data; web logs, email, web pages, etc., as well as the ability to handle failures to large block processing.