发明申请
- 专利标题： IMMUNOTHERAPY AGAINST ERBB-3 RECEPTOR
- 专利标题（中）： 对ERBB-3受体的免疫治疗
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申请号： US13882899申请日： 2011-11-02
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公开(公告)号： US20140017259A1公开(公告)日： 2014-01-16
- 发明人: Luigi Aurisicchio , Gennaro Ciliberto , Rita Mancini , Emanuele Marra , Guiseppe Roscilli
- 申请人： Luigi Aurisicchio , Gennaro Ciliberto , Rita Mancini , Emanuele Marra , Guiseppe Roscilli
- 申请人地址： IT Rome
- 专利权人： TAKIS S.R.L.
- 当前专利权人： TAKIS S.R.L.
- 当前专利权人地址： IT Rome
- 优先权： ITRM2010A000577 20101102
- 国际申请： PCT/EP2011/005529 WO 20111102
- 主分类号： C07K14/705
- IPC分类号： C07K14/705
摘要：
The present invention describes methods and pharmaceutical compositions for the treatment of cancer in mammals, more particularly in human subjects. More specifically, the invention concerns anti-tumor vaccines based upon plasmid DNA and/or genetic vectors carrying a codon-usage optimized sequence and coding for a mutant form of the ErbB-3 receptor. Furthermore, the invention refers to monoclonal antibodies directed against the ErbB-3 receptor, obtained using these methods and capable to block its activity in cancer cells.
公开/授权文献
- US09688738B2 Immunotherapy against ErbB-3 receptor 公开/授权日：2017-06-27
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