Invention Application
US20140017329A1 NANOFORMULATION AND METHODS OF USE OF THYROID RECEPTOR BETA1 AGONISTS FOR LIVER TARGETING
审中-公开
用于肝脏靶向的THYROID受体BETA激活剂的使用和方法
- Patent Title: NANOFORMULATION AND METHODS OF USE OF THYROID RECEPTOR BETA1 AGONISTS FOR LIVER TARGETING
- Patent Title (中): 用于肝脏靶向的THYROID受体BETA激活剂的使用和方法
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Application No.: US13938308Application Date: 2013-07-10
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Publication No.: US20140017329A1Publication Date: 2014-01-16
- Inventor: Shaker A. Mousa
- Applicant: Shaker A. Mousa
- Main IPC: A61K47/26
- IPC: A61K47/26 ; A61K47/12 ; A61K31/455 ; A61K31/197 ; A61K31/192
Abstract:
A composition and an associated method for hepatic targeted delivery of thyroid receptor beta1 (TRβ1) agonist to a liver of a subject. The composition includes hydrophobic nanoparticles, a liver targeting moiety exterior to each nanoparticle and covalently bonded to each nanoparticle, and at least one TRβ1 agonist encapsulated within each nanoparticle. The nanoparticles include chitosan hybrid nanoparticles, amine-modified PLGA nanoparticles, solid lipid nanoparticles, and combinations thereof. The liver targeting moiety includes Glycyrrhetinic acid (GA), Lactobionic acid (LA), or combinations thereof.
Public/Granted literature
- US09956291B2 Nanoformulation and methods of use of thyroid receptor beta1 agonists for liver targeting Public/Granted day:2018-05-01
Information query
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