发明申请
US20140017668A1 COMPOSITIONS AND METHODS FOR DETECTING AND QUANTIFYING CIRCULATING TUMOR CELLS (CTCs)
审中-公开
用于检测和定量循环肿瘤细胞（CTC）的组合物和方法
- 专利标题： COMPOSITIONS AND METHODS FOR DETECTING AND QUANTIFYING CIRCULATING TUMOR CELLS (CTCs)
- 专利标题（中）： 用于检测和定量循环肿瘤细胞（CTC）的组合物和方法
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申请号： US13807366申请日： 2011-06-30
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公开(公告)号： US20140017668A1公开(公告)日： 2014-01-16
- 发明人: Shawn Edward Lupold , Wasim Haider Chowdhury , Ping Wu , Ronald Rodriguez
- 申请人： Shawn Edward Lupold , Wasim Haider Chowdhury , Ping Wu , Ronald Rodriguez
- 申请人地址： US MD Baltimore
- 专利权人： THE JOHNS HOPKINS UNIVERSITY
- 当前专利权人： THE JOHNS HOPKINS UNIVERSITY
- 当前专利权人地址： US MD Baltimore
- 国际申请： PCT/US11/42547 WO 20110630
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12N15/86
摘要：
The present invention relates to the field of virology. More specifically, the present invention relates to the use of viral constructs to detect and quantify circulating tumor cells. In one embodiment, the present invention provides an adenovirus construct comprising (a) a cell type specific promoter that drives adenoviral replication; and (b) at least one reporter gene incorporated into the viral Major Late Transcriptional Unit. In another embodiment, an adenovirus construct comprises (a) prostate selective pro-basin promoter operably linked to the El gene; and (b) prostate specific antigen enhancer operably linked to the probasin promoter.
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