发明申请
US20140024628A1 FUMARIC ACID SALT OF 9-[4-(3-CHLORO-2-FLUORO-PHENYLAMINO)-7-METHOXY-QUINAZOLIN-6-YLOXY]-1,4-DIAZA-SPIRO[5.5]UNDECAN-5-ONE, ITS USE AS A MEDICAMENT AND THE PREPARATION THEREOF
有权
9- [4-（3-氯-2-氟 - 苯基氨基）-7-甲氧基 - 喹唑啉-6-基] -1,4-二氮杂螺[5.5]十二烷-5-磺酸的盐酸盐，其用途 作为药物及其制剂
![FUMARIC ACID SALT OF 9-[4-(3-CHLORO-2-FLUORO-PHENYLAMINO)-7-METHOXY-QUINAZOLIN-6-YLOXY]-1,4-DIAZA-SPIRO[5.5]UNDECAN-5-ONE, ITS USE AS A MEDICAMENT AND THE PREPARATION THEREOF](/docs/US/2014-01-23/US20140024628A1/abs.jpg.600x600.jpg)
- 专利标题： FUMARIC ACID SALT OF 9-[4-(3-CHLORO-2-FLUORO-PHENYLAMINO)-7-METHOXY-QUINAZOLIN-6-YLOXY]-1,4-DIAZA-SPIRO[5.5]UNDECAN-5-ONE, ITS USE AS A MEDICAMENT AND THE PREPARATION THEREOF
- 专利标题（中）： 9- [4-（3-氯-2-氟 - 苯基氨基）-7-甲氧基 - 喹唑啉-6-基] -1,4-二氮杂螺[5.5]十二烷-5-磺酸的盐酸盐，其用途 作为药物及其制剂
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申请号： US13944323申请日： 2013-07-17
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公开(公告)号： US20140024628A1公开(公告)日： 2014-01-23
- 发明人: Markus OSTERMEIER , Peter SIEGER
- 申请人： Markus OSTERMEIER , Peter SIEGER
- 申请人地址： DE Ingelheim am Rhein
- 专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人： Boehringer Ingelheim International GmbH
- 当前专利权人地址： DE Ingelheim am Rhein
- 优先权： EP12177040.8 20120719
- 主分类号： C07D403/12
- IPC分类号： C07D403/12 ; C07C51/41 ; C07C57/15 ; A61K31/517 ; A61K45/06
![FUMARIC ACID SALT OF 9-[4-(3-CHLORO-2-FLUORO-PHENYLAMINO)-7-METHOXY-QUINAZOLIN-6-YLOXY]-1,4-DIAZA-SPIRO[5.5]UNDECAN-5-ONE, ITS USE AS A MEDICAMENT AND THE PREPARATION THEREOF](/abs-image/US/2014/01/23/US20140024628A1/abs.jpg.150x150.jpg)
摘要：
The present invention relates to a compound of formula (I), which has valuable pharmacological properties, particularly an inhibiting effect on signal transduction mediated by tyrosine kinases, processes for stereoselectively preparing these compounds, particularly pharmaceutical formulations suitable for inhalation and their use for the treatment of diseases, particularly tumoral diseases, benign prostatic hyperplasia and diseases of the lungs and airways.
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