发明申请
- 专利标题： PROCESS FOR PREPARING RACEMIC NICOTINE
- 专利标题（中）： 制备非典型非甾体抗炎药的方法
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申请号： US13982095申请日： 2012-01-20
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公开(公告)号： US20140031554A1公开(公告)日： 2014-01-30
- 发明人: Guanghui Tian , Guan Wang , Xiaoguang Kong , Rongxia Zhang , Weiming Chen , Jingshan Shen
- 申请人： Guanghui Tian , Guan Wang , Xiaoguang Kong , Rongxia Zhang , Weiming Chen , Jingshan Shen
- 申请人地址： CN Shanghai CN Shandong CN Shanghai
- 专利权人： TOPHARMAN SHANGHAI CO., LTD.,TOPHARMAN SHANDONG CO., LTD.,SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- 当前专利权人： TOPHARMAN SHANGHAI CO., LTD.,TOPHARMAN SHANDONG CO., LTD.,SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- 当前专利权人地址： CN Shanghai CN Shandong CN Shanghai
- 优先权： CN201110029313.6 20110727
- 国际申请： PCT/CN2012/070630 WO 20120120
- 主分类号： C07D401/04
- IPC分类号： C07D401/04
摘要：
Provided is a process for preparing racemic nicotine from 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof using one-pot process. The process comprises the following steps: 1) in a reaction vessel, reacting 1-methyl-3-nicotinoyl-2-pyrrolidone or a salt thereof in the presence of a suitable solvent and a strong acid by heat; after the reaction is complete, cooling the same and adjusting the pH to 7-8 with alkali; and 2) directly adding a reductant into the above vessel, and after the reaction, purifying the product so as to obtain high purity racemic nicotine or a salt thereof.
公开/授权文献
- US08884021B2 Process for preparing racemic nicotine 公开/授权日：2014-11-11
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