A calibratable communications link includes multiple parallel lines. Calibration is performed at dynamically variable and/or interruptible intervals determined by an automated mechanism. Calibration is preferably initiated responsive to a command generated by an executable software process, which initiates calibration responsive to detection of a probable impending need as indicated by, e.g., temperature change, calibrated parameter drift, error rate, etc. Calibration is also preferably initiated according to probable minimal disruption of device function, as indicated by low activity level. Furthermore, in one aspect calibration may be temporarily suspended to transmit data and then resumed.