发明申请
- 专利标题： Methods of Modifying Eukaryotic Cells
- 专利标题（中）： 改造真核细胞的方法
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申请号： US14046279申请日： 2013-10-04
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公开(公告)号： US20140033337A1公开(公告)日： 2014-01-30
- 发明人: Andrew J. Murphy , George D. Yancopoulos , Margaret Karown , Lynn Macdonald , Sean Stevens
- 申请人： Andrew J. Murphy , George D. Yancopoulos , Margaret Karown , Lynn Macdonald , Sean Stevens
- 申请人地址： US NY Tarrytown
- 专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人： Regeneron Pharmaceuticals, Inc.
- 当前专利权人地址： US NY Tarrytown
- 主分类号： A01K67/027
- IPC分类号： A01K67/027
摘要：
A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.
公开/授权文献
- US09371553B2 Genetically modified mice that produce hybrid antibodies 公开/授权日：2016-06-21
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