- 专利标题： MULTI-SPECIFIC ANTIGEN-BINDING MOLECULES AND USES THEREOF
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申请号： US14019712申请日： 2013-09-06
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公开(公告)号： US20140037632A1公开(公告)日： 2014-02-06
- 发明人: Tomoyuki Igawa , Zenjiro Sampei , Tetsuo Kojima , Tetsuhiro Soeda , Atsushi Muto , Takehisa Kitazawa , Yukiko Nishida , Chifumi Imai , Tsukasa Suzuki , Kazutaka Yoshihashi
- 申请人： Chugai Seiyaku Kabushiki Kaisha
- 申请人地址： JP Tokyo
- 专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人： Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人地址： JP Tokyo
- 优先权： JP2010-257022 20101117
- 主分类号： C07K16/36
- IPC分类号： C07K16/36
摘要：
Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.
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