Invention Application
US20140039031A1 PHARMACEUTICAL FORMULATIONS OF ACETYL-11-KETO-B-BOSWELLIC ACID, DIINDOLYLMETHANE, AND CURCUMIN FOR PHARMACEUTICAL APPLICATIONS
审中-公开
乙酰基-11-酮酸B-BOSWELLIC酸，DIINDOLYLMETHANE和CURCUMIN用于药物应用的药物制剂
- Patent Title: PHARMACEUTICAL FORMULATIONS OF ACETYL-11-KETO-B-BOSWELLIC ACID, DIINDOLYLMETHANE, AND CURCUMIN FOR PHARMACEUTICAL APPLICATIONS
- Patent Title (中): 乙酰基-11-酮酸B-BOSWELLIC酸，DIINDOLYLMETHANE和CURCUMIN用于药物应用的药物制剂
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Application No.: US14001098Application Date: 2012-02-23
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Publication No.: US20140039031A1Publication Date: 2014-02-06
- Inventor: Chris Brough , Robert O. Williams, III , James W. McGinity , Dave A. Miller , Justin Hughey , Ryan Bennett
- Applicant: Chris Brough , Robert O. Williams, III , James W. McGinity , Dave A. Miller , Justin Hughey , Ryan Bennett
- Applicant Address: US TX Georgetown US TX Austin
- Assignee: Dispersol Technologies. LLC,Board of Regents, The University of Texas System
- Current Assignee: Dispersol Technologies. LLC,Board of Regents, The University of Texas System
- Current Assignee Address: US TX Georgetown US TX Austin
- International Application: PCT/US12/26407 WO 20120223
- Main IPC: A61K31/404
- IPC: A61K31/404 ; A61K31/12 ; A61K31/19
Abstract:
The present disclosure is directed to compositions and methods for formulating a pharmaceutical dosage form by forming a composition comprising acetyl-11-keto-β-boswellic acid, diindolylmethane, or curcumin with one or more pharmaceutically acceptable excipients for enhanced solubility to increase bioavailability and improve therapeutic efficacy. The composition can be processed by thermo-kinetic compounding along with conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
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