发明申请
US20140039219A1 Method of Making 6-Aminocaproic Acid As Active Pharmaceutical Ingredient
有权
制备6-氨基己酸作为活性药物成分的方法
- 专利标题： Method of Making 6-Aminocaproic Acid As Active Pharmaceutical Ingredient
- 专利标题（中）： 制备6-氨基己酸作为活性药物成分的方法
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申请号： US13660126申请日： 2012-10-25
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公开(公告)号： US20140039219A1公开(公告)日： 2014-02-06
- 发明人: Jien-Heh Tien , Chu-yi Pang
- 申请人： Jien-Heh Tien , Chu-yi Pang
- 申请人地址： TW Taoyuan County
- 专利权人： Sunny Pharmtech Inc.
- 当前专利权人： Sunny Pharmtech Inc.
- 当前专利权人地址： TW Taoyuan County
- 优先权： TW101128069 20120803
- 主分类号： C07C227/22
- IPC分类号： C07C227/22
摘要：
The present invention provides a method for making 6-aminocaproic acid as an active pharmaceutical ingredient. The method comprises: performing a hydrolysis procedure to have ε-caprolactam react with acid or base to generate a first reaction mixture, performing a modification procedure to have a solubility regulating agent reacts with 6-aminocaproic acid in the first reaction mixture to form a second reaction mixture including an aminocaproic acid intermediate, performing a separation procedure to have the intermediate separated from the second reaction mixture and performing a hydrogenation procedure to have the aminocaproic acid intermediate hydrogenated to form a 6-aminocaproic acid product.
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