发明申请
- 专利标题： BINDING PROTEINS TO INHIBITORS OF COAGULATION FACTORS
- 专利标题（中）： 绑定蛋白与凝血因子的抑制剂
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申请号： US13980431申请日： 2012-01-17
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公开(公告)号： US20140050743A1公开(公告)日： 2014-02-20
- 发明人: Frank Dittmer , Anja Buchmüller , Christoph Gerdes , Adrian Tersteegen , Mark Jean Gnoth , Lars Linden , Axel Harrenga , Joanna Grudzinska-Goebel , Mario Jeske , Martina Schäfer , Jörg Birkenfeld , Holger Paulsen , Ricarda Finnern , Anke Mayer-Bartschmid , Andrea Eicker , Simone Greven , Susanne Steinig
- 申请人： Frank Dittmer , Anja Buchmüller , Christoph Gerdes , Adrian Tersteegen , Mark Jean Gnoth , Lars Linden , Axel Harrenga , Joanna Grudzinska-Goebel , Mario Jeske , Martina Schäfer , Jörg Birkenfeld , Holger Paulsen , Ricarda Finnern , Anke Mayer-Bartschmid , Andrea Eicker , Simone Greven , Susanne Steinig
- 申请人地址： DE Monheim
- 专利权人： BAYER INTELLECTUAL PROPERTY GMBH
- 当前专利权人： BAYER INTELLECTUAL PROPERTY GMBH
- 当前专利权人地址： DE Monheim
- 优先权： EP11151410.5 20110119
- 国际申请： PCT/EP2012/050595 WO 20120117
- 主分类号： C07K16/44
- IPC分类号： C07K16/44
摘要：
The present invention relates to the identification and use of antigen-binding regions, antibodies, antigen-binding antibody fragments and antibody mimetics, neutralizing the anti-coagulant effect of an anticoagulant in vitro and/or in vivo. Antibodies and functional fragments of the invention and antibody mimetics can be used to specifically reverse the pharmacological effect of an anticoagulant e.g. a FXa inhibitor for therapeutic (antidote) and/or diagnostic purposes. The invention also provides nucleic acid sequences encoding foregoing molecules, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
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