发明申请
US20140051085A1 DIRECT REPROGRAMMING OF HUMAN FIBROBLASTS TO FUNCTIONAL NEURONS UNDER DEFINED CONDITIONS
审中-公开
人体纤维素在定义条件下对功能性神经元的直接重现
- 专利标题： DIRECT REPROGRAMMING OF HUMAN FIBROBLASTS TO FUNCTIONAL NEURONS UNDER DEFINED CONDITIONS
- 专利标题（中）： 人体纤维素在定义条件下对功能性神经元的直接重现
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申请号： US14001279申请日： 2012-03-01
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公开(公告)号： US20140051085A1公开(公告)日： 2014-02-20
- 发明人: Sheng Ding , Rajesh Ambasudhan
- 申请人： Sheng Ding , Rajesh Ambasudhan
- 申请人地址： US CA La Jolla
- 专利权人： The Scripps Research Institute
- 当前专利权人： The Scripps Research Institute
- 当前专利权人地址： US CA La Jolla
- 国际申请： PCT/US12/27313 WO 20120301
- 主分类号： C12N5/0793
- IPC分类号： C12N5/0793 ; G01N33/569 ; C12Q1/68 ; C12N15/85 ; G01N33/487
摘要：
The present invention provides methods of generating a neuronal cell from a differentiated non-neuronal cell by increasing the amount of a miR-124 microRNA, a MYT1L transcription factor, and a BRN2 transcription factor in the differentiated non-neuronal cell.
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