发明申请
- 专利标题： MUTEINS OF HUMAN LIPOCALIN 2 WITH AFFINITY FOR CTLA-4
- 专利标题（中）： 人类LIPOCALIN 2与CTLA-4具有亲和力
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申请号： US13991226申请日： 2011-12-02
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公开(公告)号： US20140051645A1公开(公告)日： 2014-02-20
- 发明人: Gabriele Matschiner , Andreas Hohlbaum , Arne Skerra
- 申请人： Gabriele Matschiner , Andreas Hohlbaum , Arne Skerra
- 专利权人： PIERIS AG
- 当前专利权人： PIERIS AG
- 优先权： EP10193401.6 20101202
- 国际申请： PCT/EP2011/071650 WO 20111202
- 主分类号： C07K14/435
- IPC分类号： C07K14/435
摘要：
The present invention relates to novel, specific-binding therapeutic and/or diagnostic proteins directed against Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) also known as CD152, which proteins preferably are muteins of a lipocalin protein, more preferably of lipocalin 2 (Lcn2 or NGAL). The invention also relates to nucleic acid molecules encoding such proteins and to methods for generation and use of such proteins and nucleic acid molecules. Accordingly, the invention also is directed to pharmaceutical and/or diagnostic compositions comprising such lipocalin proteins, including uses of these proteins.
公开/授权文献
- US09221885B2 Muteins of human lipocalin 2 with affinity for CTLA-4 公开/授权日：2015-12-29
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