- 专利标题： THIOPYRIMIDINE-BASED COMPOUNDS AND USES THEREOF
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申请号： US13861344申请日： 2013-04-11
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公开(公告)号： US20140051703A1公开(公告)日： 2014-02-20
- 发明人: David Gerard BOURKE , Xianyong Bu , Christopher John Burns , Anthony Nicholas Cuzzupe , John Thomas Feutrill , Tracy Leah Nero , Beata Maria Blannin , Jun Zeng , Shaun Patrick Gaynor
- 申请人： Cytopia Research Pty Ltd.
- 申请人地址： AU Richmond
- 专利权人： Cytopia Research Pty Ltd.
- 当前专利权人： Cytopia Research Pty Ltd.
- 当前专利权人地址： AU Richmond
- 主分类号： C07D413/12
- IPC分类号： C07D413/12 ; C07D403/12 ; C07D239/38
摘要：
The present invention relates to thiopyrimidine-based compounds that are inhibitors of protein kinases including JAK kinases. In particular, the compounds are selective for JAK1, JAK2 or JAK3 kinases and combinations thereof such as JAK1 and JAK2. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases and vascular diseases.
公开/授权文献
- US09040549B2 Thiopyrimidine-based compounds and uses thereof 公开/授权日：2015-05-26
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