发明申请
- 专利标题： METHOD FOR THE PRODUCTION OF RECOMBINANT HUMAN FACTOR VIII
- 专利标题（中）： 生产重组人因子VIII的方法
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申请号： US14004235申请日： 2011-03-11
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公开(公告)号： US20140051832A1公开(公告)日： 2014-02-20
- 发明人: Marcos A. A. Demasi , Mari Cleide Sogayar , Christian Colin
- 申请人： Marcos A. A. Demasi , Mari Cleide Sogayar , Christian Colin
- 申请人地址： BR São Paulo
- 专利权人： UNIVERSIDADE DE SÃO PAULO - USP
- 当前专利权人： UNIVERSIDADE DE SÃO PAULO - USP
- 当前专利权人地址： BR São Paulo
- 国际申请： PCT/BR11/00069 WO 20110311
- 主分类号： C07K14/755
- IPC分类号： C07K14/755
摘要：
The object of the present invention is to provide methods for the production of recombinant human Factor VIII, employing specific endoproteases, thus assuring full proteolytic processing of said factor even during its biosynthesis, consequently avoiding additional purification steps. Other objects of the present invention are the recombinant human Factor VIII as obtained by said methods, pharmaceutical compositions, related uses and therapeutic methods.
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