发明申请
US20140057893A1 SUBSTITUTED CYCLOPROPLY COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
有权
取代的环状化合物，包含这些化合物的组合物和处理方法
- 专利标题： SUBSTITUTED CYCLOPROPLY COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
- 专利标题（中）： 取代的环状化合物，包含这些化合物的组合物和处理方法
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申请号： US14110332申请日： 2012-04-05
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公开(公告)号： US20140057893A1公开(公告)日： 2014-02-27
- 发明人: Scott Edmondson , Zhiqiang Guo , Harold B. Wood , Andrew W. Stamford , Michael W. Miller , Duane E. DeMong , Gregori J. Morriello , Rajan Anand , Vincent J. Colandrea , Megan Macala , Milana Maletic , Cheng Zhu , Yuping Zhu , Wanying Sun , Kake Zhao , Yong Huang , Joel M. Harris , Lehua Chang , Nam Fung Kar , Zhiyong Hu , Liping Wang , Bowei Wang , Ping Liu , Jason W. Szewczyk , William B. Geiss
- 申请人： Scott Edmondson , Zhiqiang Guo , Harold B. Wood , Andrew W. Stamford , Michael W. Miller , Duane E. DeMong , Gregori J. Morriello , Rajan Anand , Vincent J. Colandrea , Megan Macala , Milana Maletic , Cheng Zhu , Yuping Zhu , Wanying Sun , Kake Zhao , Yong Huang , Joel M. Harris , Lehua Chang , Nam Fung Kar , Zhiyong Hu , Liping Wang , Bowei Wang , Ping Liu , Jason W. Szewczyk , William B. Geiss
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US12/32303 WO 20120405
- 主分类号： C07D513/04
- IPC分类号： C07D513/04 ; C07D413/14 ; C07D413/04 ; C07D498/04 ; C07D405/04 ; C07D471/04 ; C07D487/04 ; C07D401/12 ; C07D211/22
摘要：
Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included