发明申请
- 专利标题： Method for Producing Glycopeptide Having Sialyl Sugar Chain, Sialyl Sugar Chain-Added Amino Acid Derivative to be Used in Same, and Glycopeptide
- 专利标题（中）： 具有唾液酸糖链的糖肽，用于同时使用的唾液酸糖链氨基酸衍生物和糖肽的方法
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申请号： US14004122申请日： 2012-03-05
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公开(公告)号： US20140058062A1公开(公告)日： 2014-02-27
- 发明人: Yasuhiro Kajihara , Masumi Murakami , Kazuyuki Ishii
- 申请人： Yasuhiro Kajihara , Masumi Murakami , Kazuyuki Ishii
- 申请人地址： JP Kyoto
- 专利权人： Glytech, Inc.
- 当前专利权人： Glytech, Inc.
- 当前专利权人地址： JP Kyoto
- 优先权： JP2011-053644 20110310; JP2012-021367 20120202
- 国际申请： PCT/JP2012/055543 WO 20120305
- 主分类号： C07K14/00
- IPC分类号： C07K14/00
摘要：
[Technical Promblem]To provide a method for manufacturing that enables to obtain a targeted glycopeptide harboring a sialyl sugar chain in high yield without decomposing sialic acid at a non-reducing terminal of sugar chain when the glycopeptide is synthesized by a Boc solid phase synthesis method.[Solution to Problem]The present invention is characterized in that the Boc-sialylglycosylated amino acid derivative used in Boc solid phase synthesis method is one where the carboxyl group of the sialic acid at the sugar chain non-reducing terminal is protected with a phenacyl group.
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