A distributed antenna system includes a master unit including a downlink RF input operable to receive an RF input signal from a downlink port of a base station, a first optical port, and a second optical port. The distributed antenna system also includes a first remote unit coupled to the first optical port. The first remote unit comprises a downlink antenna port and a first uplink antenna port and a second remote unit coupled to the second optical port of the master unit. The second remote unit comprises a downlink antenna port and a second uplink antenna port. The master unit is operable to transmit a first RF signal associated with the first RF uplink signal to a first uplink port of the base station and transmit a second RF signal associated with the second RF uplink signal to a second uplink port of the base station.