Invention Application
US20140080765A1 NOVEL METALLOPROTEIN AND PROCESS FOR PRODUCING SAME, AND PROPHYLACTIC OR THERAPEUTIC AGENT FOR CORNEAL AND CONJUNCTIVAL DISEASES COMPRISING SAID METALLOPROTEIN
审中-公开
新型金属蛋白酶及其生产方法，以及含有金属蛋白酶的正常和连续性疾病的预防或治疗药物
- Patent Title: NOVEL METALLOPROTEIN AND PROCESS FOR PRODUCING SAME, AND PROPHYLACTIC OR THERAPEUTIC AGENT FOR CORNEAL AND CONJUNCTIVAL DISEASES COMPRISING SAID METALLOPROTEIN
- Patent Title (中): 新型金属蛋白酶及其生产方法，以及含有金属蛋白酶的正常和连续性疾病的预防或治疗药物
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Application No.: US14118879Application Date: 2012-05-18
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Publication No.: US20140080765A1Publication Date: 2014-03-20
- Inventor: Akihiro Higuchi , Hiroyoshi Inoue , Kazuo Tsubota
- Applicant: Akihiro Higuchi , Hiroyoshi Inoue , Kazuo Tsubota
- Applicant Address: JP Nagoya, Aichi JP Minato-ku, Tokyo
- Assignee: KOWA COMPANY, LTD.,KEIO UNIVERSITY
- Current Assignee: KOWA COMPANY, LTD.,KEIO UNIVERSITY
- Current Assignee Address: JP Nagoya, Aichi JP Minato-ku, Tokyo
- Priority: JP2011-113012 20110520; JP2011-113013 20110520
- International Application: PCT/JP2012/062752 WO 20120518
- Main IPC: C07K14/79
- IPC: C07K14/79
Abstract:
The present invention provides: a novel metalloprotein, i.e., selenium-lactoferrin; and a process for producing the metalloprotein. Selenium-lactoferrin according to the present invention can be produced suitably by adding a selenium salt to a solution containing lactoferrin and/or apolactoferrin and then subjecting the resultant mixed solution to dialysis or ultrafiltration.Selenium-lactoferrin according to the present invention has an excellent therapeutic effect on corneal and conjunctival diseases, and is suitable for mass production on an industrial scale.
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