发明申请
- 专利标题： Substituted Benzoazepines As Toll-Like Receptor Modulators
- 专利标题（中）： 取代的苯并氮杂类似受体调节剂
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申请号： US13979634申请日： 2012-01-12
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公开(公告)号： US20140088085A1公开(公告)日： 2014-03-27
- 发明人: Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones , James Jeffry Howbert , Robert Hershberg , Joseph P. Lyssikatos , Hong Woon Yang
- 申请人： Laurence E. Burgess , George A. Doherty , C. Todd Eary , Robert D. Groneberg , Zachary Jones , James Jeffry Howbert , Robert Hershberg , Joseph P. Lyssikatos , Hong Woon Yang
- 申请人地址： US CO Boulder US WA Seattle
- 专利权人： ARRAY BIOPHARMA, INC,VENTIRX PHARMACEUTICALS, INC
- 当前专利权人： ARRAY BIOPHARMA, INC,VENTIRX PHARMACEUTICALS, INC
- 当前专利权人地址： US CO Boulder US WA Seattle
- 国际申请： PCT/US12/21116 WO 20120112
- 主分类号： C07D223/16
- IPC分类号： C07D223/16 ; C07D243/14 ; C07D487/04 ; C07D401/12
摘要：
Provided are compositions and methods useful for modulation of signaling through the Toll-like receptors TLR7 and/or TLR8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease.