发明申请
- 专利标题: ANTI-CANCER ACTIVITY OF NOVEL BICYCLIC HETEROCYCLES
- 专利标题(中): 新型双环杂交体的抗癌活性
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申请号: US13823413申请日: 2011-09-08
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公开(公告)号: US20140088088A1公开(公告)日: 2014-03-27
- 发明人: Jean Herman , Thierry Louat
- 申请人: Jean Herman , Thierry Louat
- 申请人地址: BE Leuven
- 专利权人: Katholieke Universiteit Leuven, K.U. Leuven R&D
- 当前专利权人: Katholieke Universiteit Leuven, K.U. Leuven R&D
- 当前专利权人地址: BE Leuven
- 优先权: GB1015411.0 20100915
- 国际申请: PCT/IB2011/002248 WO 20110908
- 主分类号: C07D513/04
- IPC分类号: C07D513/04 ; C07D495/04 ; C07D473/32 ; C07D498/04
摘要:
The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, Formulas (I), (II), (III) and (IV) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R11, and R12 are as defined in the claim 1 or as described in detail in the description of the invention, and to the use of said compounds to treat or prevent proliferative disorders and their use to manufacture a medicine to treat or prevent proliferative disorders, particularly cancer such as leukemia. The present invention also relates to pharmaceutical compositions of said compounds and the use of said pharmaceutical compositions to treat or prevent proliferative disorders. The present invention further relates to the use of said compounds as biologically active ingredients, more specifically as medicaments for the treatment of proliferative disorders and pathologic conditions such as, but not limited to, cancer such as leukemia.
公开/授权文献
- US09573966B2 Anti-cancer activity of novel bicyclic heterocycles 公开/授权日:2017-02-21