发明申请
US20140088197A1 MIXED CRYSTAL AGOMELATINE (FORM VIII), PREPARATION METHOD AND USE THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
审中-公开
混合水性聚酰胺（形式VIII），其制备方法及其用途及其含有的药物组合物
- 专利标题： MIXED CRYSTAL AGOMELATINE (FORM VIII), PREPARATION METHOD AND USE THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
- 专利标题（中）： 混合水性聚酰胺（形式VIII），其制备方法及其用途及其含有的药物组合物
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申请号： US14006484申请日： 2012-03-22
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公开(公告)号： US20140088197A1公开(公告)日： 2014-03-27
- 发明人: Yu Huang , QING Long , Xueyan Zhu , Hanbin Shan , Zhedong Yuan , Xiong Yu
- 申请人： Yu Huang , QING Long , Xueyan Zhu , Hanbin Shan , Zhedong Yuan , Xiong Yu
- 申请人地址： FR SURESNES CEDEX
- 专利权人： LES LABORATORIES SERVIER
- 当前专利权人： LES LABORATORIES SERVIER
- 当前专利权人地址： FR SURESNES CEDEX
- 优先权： CN201110070634.0 20110323
- 国际申请： PCT/CN12/72818 WO 20120322
- 主分类号： C07C233/08
- IPC分类号： C07C233/08 ; A61K31/165
摘要：
The present invention provides a mixed crystalline form VIII of agomelatine, its method of preparation, application and pharmaceutical composition. The said mixed crystal consists mainly of crystalline form VI of agomelatine. The said mixed crystalline form is stable and has good reproducibility. Through stability tests, it has been found to be superior to the crystalline form VI in terms of stability. As a result, the crystalline form VIII of the present invention possesses advantages in pharmaceutical preparation.