发明申请
US20140088298A9 CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION
审中-公开
包含羟基烷基淀粉和细胞毒素的方法及其制备方法
- 专利标题： CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION
- 专利标题（中）： 包含羟基烷基淀粉和细胞毒素的方法及其制备方法
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申请号： US13809194申请日： 2011-07-11
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公开(公告)号： US20140088298A9公开(公告)日： 2014-03-27
- 发明人: Helmut Knoller , Dominik Heckmann , Frank Hacket , Norbert Zander , Frank Nocken , Saswata Lahiri , Nitin Gupta , Sunil Sanghani , Azim Abul , Hemant Kumar Singh , Sandeep Grewal , Sandeep Kaur
- 申请人： Helmut Knoller , Dominik Heckmann , Frank Hacket , Norbert Zander , Frank Nocken , Saswata Lahiri , Nitin Gupta , Sunil Sanghani , Azim Abul , Hemant Kumar Singh , Sandeep Grewal , Sandeep Kaur
- 申请人地址： DE Bad Homburg
- 专利权人： Fresenius Kabi Deutschland GmbH
- 当前专利权人： Fresenius Kabi Deutschland GmbH
- 当前专利权人地址： DE Bad Homburg
- 优先权： EP10007108.3 20100709
- 国际申请： PCT/EP2011/003459 WO 20110711
- 主分类号： A61K47/36
- IPC分类号： A61K47/36
摘要：
The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxy-yalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.
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